Demineralization increases the osteoinductive ability because growth factors such as BMP becomes viable and induce mesenchymal cells to differentiate into osteoblast. The lyophilization technology made it possible to increase the shelf life DFDBA such as CortiOss-D so it can be stored for a long period of time. CortiOss-D can be rehydrated with patient’s blood or saline solution and is provided in a specially designed vial container for user’s convenience.
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